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1

War in the time of COVID-19: humanitarian catastrophe in Nagorno-Karabakh and Armenia

Kazaryan, Airazat M, Edwin, BjÃ¸rn, Darzi, Ara, Tamamyan, Gevorg N, Sahakyan, Mushegh A, Aghayan, Davit L, Fretland, Ãsmund A, Yaqub, Sheraz, Gayet, Brice

Journal:

The Lancet Global Health

Year:

2020

File:

PDF, 53 KB

2020

2

Discovery of Highly Selective and Orally Active Lysophosphatidic Acid Receptor-1 Antagonists with Potent Activity on Human Lung Fibroblasts

Qian, Yimin, Hamilton, Matthew, Sidduri, Achyutharao, Gabriel, Stephen, Ren, Yonglin, Peng, Ruoqi, Kondru, Rama, Narayanan, Arjun, Truitt, Terry, Hamid, Rachid, Chen, Yun, Zhang, Lin, Fretland, Adrian

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 1.94 MB

english, 2012

3

Design of Annulated Pyrazoles as Inhibitors of HIV-1 Reverse Transcriptase ∥

Sweeney, Zachary K., Harris, Seth F., Arora, Nidhi, Javanbakht, Hassan, Li, Yu, Fretland, Jennifer, Davidson, James P., Billedeau, J. Roland, Gleason, Shelley K., Hirschfeld, Donald, Kennedy-Smith, Jo

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 708 KB

english, 2008

4

Evaluation of Various Static In Vitro–In Vivo Extrapolation Models for Risk Assessment of the CYP3A Inhibition Potential of an Investigational Drug

Vieira, Md L T, Kirby, B, Ragueneau-Majlessi, I, Galetin, A, Chien, J Y L, Einolf, H J, Fahmi, O A, Fischer, V, Fretland, A, Grime, K, Hall, S D, Higgs, R, Plowchalk, D, Riley, R, Seibert, E, Skordos,

Journal:

Clinical Pharmacology & Therapeutics

Year:

2014

Language:

english

File:

PDF, 891 KB

english, 2014

5

Utility of Intersystem Extrapolation Factors in Early Reaction Phenotyping and the Quantitative Extrapolation of Human Liver Microsomal Intrinsic Clearance Using Recombinant Cytochromes P450

Chen, Y., Liu, L., Nguyen, K., Fretland, A. J.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 246 KB

english, 2011

6

Open versus laparoscopic liver resection of colorectal metastases: The Oslo-CoMet study

Fretland, Å.A., Kazaryan, A.M., Bjørnbeth, B.A., Røsok, B., Flatmark, K., Andersen, M.H., Bjørnelv, G.M.W., Fagerland, M.W., Mollnes, T.E., Kristiansen, R., Edwin, B.

Journal:

Year:

2016

Language:

english

File:

PDF, 136 KB

english, 2016

7

The European Experience in Laparoscopic Pancreatic Resections

Sahakyan, Mushegh A., Røsok, Bård I., Kleive, Dyre, Fretland, Åsmund Avdem, Kazaryan, Airazat M., Labori, Knut Jørgen, Edwin, Bjørn

Journal:

Journal of the American College of Surgeons

Year:

2018

Language:

english

File:

PDF, 66 KB

english, 2018

8

Intravenous Patient-controlled Analgesia Versus Thoracic Epidural Analgesia After Open Liver Surgery

Hausken, John, Fretland, Åsmund Avdem, Edwin, Bjørn, Andersen, Marit Helen, Dagenborg, Vegar Johansen, Bjørnelv, Gudrun Maria Waaler, Kristiansen, Ronny, Røysland, Kjetil, Kvarstein, Gunnvald, Tønness

Journal:

Annals of Surgery

Year:

2019

File:

PDF, 416 KB

2019

9

Improving the Accuracy of Predicted Human Pharmacokinetics: Lessons Learned from the AstraZeneca Drug Pipeline Over Two Decades

Davies, Michael, Jones, Rhys D.O., Grime, Ken, Jansson-LÃ¶fmark, Rasmus, Fretland, Adrian J., Winiwarter, Susanne, Morgan, Paul, McGinnity, Dermot F.

Journal:

Trends in Pharmacological Sciences

Year:

2020

File:

PDF, 2.70 MB

2020

10

DNA adduct levels and absence of tumors in female rapid and slow acetylator congenic hamsters administered the rat mammary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

Adrian J. Fretland, Uday S. Devanaboyina, Norma A. Nangju, Matthew A. Leff, Gong H. Xiao, Stephanie J. Webb, Mark A. Doll, David W. Hein

Journal:

Journal of Biochemical and Molecular Toxicology

Year:

2001

Language:

english

File:

PDF, 88 KB

english, 2001

11

Physiological modeling and assessments of regional drug bioavailability of danoprevir to determine whether a controlled release formulation is feasible

Micaela B. Reddy, Alyson Connor, Barbara J. Brennan, Peter N. Morcos, Amy Zhou, Pamela McLawhon, Adrian Fretland, Philip Evans, Patrick Smith, Jonathan Q. Tran

Journal:

Biopharmaceutics & Drug Disposition

Year:

2011

Language:

english

File:

PDF, 299 KB

english, 2011

12

ChemInform Abstract: Inhibition of Nitric Oxide Synthase and Prospects for Therapy in Inflammatory Diseases

D. J. FRETLAND, J. R. CONNOR, B. S. PITZELE, M. G. CURRIE, P. T. MANNING

Journal:

Year:

1998

File:

PDF, 25 KB

1998

13

Optical isomers of a leukotriene b4 antagonist have differential effects on granulocyte diapedesis in the guinea pig dermis

Donald J. Fretland, Deborah L. Widomski, Charles P. Anglin, Stella Yu, Stevan W. Djuric

Journal:

Year:

1992

Language:

english

File:

PDF, 312 KB

english, 1992

14

Diphenyl Ether Non-Nucleoside Reverse Transcriptase Inhibitors with Excellent Potency Against Resistant Mutant Viruses and Promising Pharmacokinetic Properties

Zachary K. Sweeney, Joshua J. Kennedy-Smith, Jeffrey Wu, Nidhi Arora, J. Roland Billedeau, James P. Davidson, Jennifer Fretland, Julie Q. Hang, Gabrielle M. Heilek, Seth F. Harris, Donald Hirschfeld,

Journal:

Year:

2009

Language:

english

File:

PDF, 521 KB

english, 2009

15

Cover Picture: Diphenyl Ether Non-Nucleoside Reverse Transcriptase Inhibitors with Excellent Potency Against Resistant Mutant Viruses and Promising Pharmacokinetic Properties (ChemMedChem 1/2009)

Zachary K. Sweeney, Joshua J. Kennedy-Smith, Jeffrey Wu, Nidhi Arora, J. Roland Billedeau, James P. Davidson, Jennifer Fretland, Julie Q. Hang, Gabrielle M. Heilek, Seth F. Harris, Donald Hirschfeld,

Journal:

Year:

2009

Language:

english

File:

PDF, 879 KB

english, 2009

16

Effects of single nucleotide polymorphisms in human N-acetyltransferase 2 on metabolic activation (O-acetylation) of heterocyclic amine carcinogens

David W. Hein, Adrian J. Fretland, Mark A. Doll

Journal:

International Journal of Cancer

Year:

2006

Language:

english

File:

PDF, 79 KB

english, 2006

17

Tissue distribution of N-acetyltransferase 1 and 2 catalyzing the N-acetylation of 4-aminobiphenyl and O-acetylation of N-hydroxy-4-aminobiphenyl in the congenic rapid and slow acetylator Syrian hamster

David W. Hein, Mark A. Doll, Donald E. Nerland, Adrian J. Fretland

Journal:

Molecular Carcinogenesis

Year:

2006

Language:

english

File:

PDF, 154 KB

english, 2006

18

Determination of HumanNAT2Acetylator Genotype by Restriction Fragment-Length Polymorphism and Allele-Specific Amplification

Mark A. Doll, Adrian J. Fretland, Anne C. Deitz, David W. Hein

Journal:

Analytical Biochemistry

Year:

1995

Language:

english

File:

PDF, 147 KB

english, 1995

19

Discovery of triazolinone non-nucleoside inhibitors of HIV reverse transcriptase

Zachary K. Sweeney, Sahaja Acharya, Andrew Briggs, James P. Dunn, Todd R. Elworthy, Jennifer Fretland, Anthony M. Giannetti, Gabrielle Heilek, Yu Li, Ann C. Kaiser, Michael Martin, Y. David Saito, Mar

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 177 KB

english, 2008

20

Synthesis, structural analysis, and SAR studies of triazine derivatives as potent, selective Tie-2 inhibitors

Brian L. Hodous, Stephanie D. Geuns-Meyer, Paul E. Hughes, Brian K. Albrecht, Steve Bellon, Sean Caenepeel, Victor J. Cee, Stuart C. Chaffee, Maurice Emery, Jenne Fretland, Paul Gallant, Yan Gu, Rebec

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 252 KB

english, 2007

21

Pyridyl-pyrimidine benzimidazole derivatives as potent, selective, and orally bioavailable inhibitors of Tie-2 kinase

Victor J. Cee, Alan C. Cheng, Karina Romero, Steve Bellon, Christopher Mohr, Douglas A. Whittington, Annette Bak, James Bready, Sean Caenepeel, Angela Coxon, Holly L. Deak, Jenne Fretland, Yan Gu, Bri

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 291 KB

english, 2009

22

Inflammation of guinea pig dermis

D. J. Fretland, D. L. Widomski, J. M. Zemaitis, R. E. Walsh, S. Levin, S. W. Djuric, R. L. Shone, B. S. Tsai, T. S. Gaginella

Journal:

Year:

1990

Language:

english

File:

PDF, 829 KB

english, 1990

23

Effect of a leukotriene B4receptor antagonist on leukotriene B4-induced neutrophil chemotaxis in cavine dermis

D. J. Fretland, D. L. Widomski, J. M. Zemaitis, S. W. Djurić, R. L. Shone

Journal:

Year:

1989

Language:

english

File:

PDF, 234 KB

english, 1989

24

Colonic inflammation in the rabbit induced by phorbol-12-myristate-13-acetate

D. J. Fretland, D. L. Widomski, S. Levin, T. S. Gaginella

Journal:

Year:

1990

Language:

english

File:

PDF, 560 KB

english, 1990

25

Leukotriene B4-induced granulocyte trafficking in guinea pig dermis

D. J. Fretland, D. L. Widomski, C. P. Anglin, T. D. Penning, S. Yu, S. W. Djuric

Journal:

Year:

1993

Language:

english

File:

PDF, 398 KB

english, 1993

26

Mucosal protective activity of prostaglandin analogs in rodent colonic inflammation

D. J. Fretland, D. L. Widomski, C. P. Anglin, R. E. Walsh, S. Levin, A. F. Gasiecki, P. W. Collins

Journal:

Year:

1992

Language:

english

File:

PDF, 587 KB

english, 1992

27

Interleukin 8 and mast cell-generated tumor necrosis factor-αin neutrophil recruitment

Y. Zhang, B. F. Ramos, B. Jakschik, M. P. Baganoff, C. L. Deppeler, D. M. Meyer, D. L. Widomski, D. J. Fretland, M. A. Bolanowski

Journal:

Year:

1995

Language:

english

File:

PDF, 764 KB

english, 1995

28

Dermal inflammation in primates, mice, and guinea pigs: Attenuation by second-generation leukotriene B4receptor antagonist, SC-53228

D. J. Fretland, R. Gokhale, L. Mathur, D. A. Baron, S. K. Paulson, J. Stolzenbach

Journal:

Year:

1995

Language:

english

File:

PDF, 1.15 MB

english, 1995

29

Antiinflammatory effects of second-generation leukotriene B4receptor antagonist, SC-53228: Impact upon Leukotriene B4- and 12(R)-HETE- mediated events

D. J. Fretland, C. P. Anglin, M. Bremer, P. Isakson, D. L. Widomski, S. K. Paulson, S. H. Docter, S. W. Djuric, T. D. Penning, S. Yu, J. P. McKearn

Journal:

Year:

1995

Language:

english

File:

PDF, 631 KB

english, 1995

30

Identification and characterization of rhesus macaque interleukin-8

J. C. Minnerly, M. P. Baganoff, C. L. Deppeler, B. T. Keller, S. R. Rapp, D. L. Widomski, D. J. Fretland, M. A. Bolanowski

Journal:

Year:

1995

Language:

english

File:

PDF, 923 KB

english, 1995

31

Pharmacological activity of the second generation leukotriene B4receptor antagonist, SC-53228:

D. J. Fretland, C. P. Anglin, D. Widomski, D. A. Baron, T. Maziasz, P. F. Smith

Journal:

Year:

1995

Language:

english

File:

PDF, 1.11 MB

english, 1995

32

The pharmacokinetics and metabolism of SC-53228, a specific leukotriene B4receptor antagonist

S. Paulson, Y. Readus, S. Bulik, G. Schoenhard, J. Stolzenbach, D. Fretland

Journal:

Inflammation Research

Year:

1995

Language:

english

File:

PDF, 136 KB

english, 1995

33

3(S)-hydroxy-leukotriene B4is a potent granulocyte chemotaxin in the guinea pig dermis

D. Fretland, C. Anglin, D. Baron, D. Widomski, K. Chauhan, R. Bhatt, J. Falck

Journal:

Inflammation Research

Year:

1995

Language:

english

File:

PDF, 176 KB

english, 1995

34

The design and synthesis of second generation leukotriene B4(LTB4) receptor antagonists related to SC-41930

T. D. Penning, S. W. Djuric, S. H. Docter, S. S. Yu, D. Spangler, C. P. Anglin, D. J. Fretland, J. F. Kachur, R. H. Keith, B. S. Tsai, D. Villani-Price, D. L. Widomski

Journal:

Inflammation Research

Year:

1993

Language:

english

File:

PDF, 180 KB

english, 1993

35

Inflammatory mediator changes in cotton-top tamarins (CTT) after SC-41930 anti-colitic therapy

N. Clapp, M. Henke, R. Hansard, R. Carson, R. Walsh, D. Widomski, C. Anglin, D. Fretland

Journal:

Inflammation Research

Year:

1993

Language:

english

File:

PDF, 169 KB

english, 1993

36

Anti-colitic efficacy of SC-41930 in colitic cotton-top tamarins

N. Clapp, M. Henke, R. Hansard, R. Carson, D. Fretland

Journal:

Inflammation Research

Year:

1993

Language:

english

File:

PDF, 184 KB

english, 1993

37

The effect of leukotriene-B4receptor antagonist, SC-41930, on acetic acid-induced colonic inflammation

D. J. Fretland, S. Levin, B. S. Tsai, S. W. Djurić, D. L. Widomski, J. M. Zemaitis, R. L. Shone, R. F. Bauer

Journal:

Inflammation Research

Year:

1989

Language:

english

File:

PDF, 173 KB

english, 1989

38

Anti-inflammatory activity of the leukotriene B4receptor antagonist, SC-41930, in colitic cotton-top tamarins

N. Clapp, M. Henke, R. Hansard, R. Carson, D. Widomski, C. Anglin, R. Walsh, S. Djuric, D. Fretland

Journal:

Inflammation Research

Year:

1994

Language:

english

File:

PDF, 172 KB

english, 1994

39

Modulation of the chemotactic properties of complement fragments C5a and C3 by the anti-inflammatory agent, SC-41930

D. J. Fretland, D. L. Widomski, C. P. Anglin, S. Levin, T. S. Gaginella

Journal:

Inflammation Research

Year:

1991

Language:

english

File:

PDF, 179 KB

english, 1991

40

Effects of the prostaglandin analogue misoprostol on inflammatory mediator release by human monocytes

D. L. Widomski, R. E. Walsh, D. A. Baron, M. I. Hidvegi, D. J. Fretland, P. W. Collins, T. S. Gaginella

Journal:

Inflammation Research

Year:

1991

Language:

english

File:

PDF, 152 KB

english, 1991

41

Effect of the leukotriene B4receptor antagonist, SC-41930, on experimental allergic encephalomyelitis (EAE) in the guinea pig

D. J. Fretland, D. L. Widomski, R. L. Shone, S. Levin, T. S. Gaginella

Journal:

Inflammation Research

Year:

1991

Language:

english

File:

PDF, 173 KB

english, 1991

42

Inflammatory mediators in cotton-top tamarins (CTT) with acute and chronic colitis

N. K. Clapp, M. A. Henke, R. M. Hansard, R. E. Walsh, D. L. Widomski, C. P. Anglin, D. J. Fretland, T. S. Gaginella

Journal:

Inflammation Research

Year:

1991

Language:

english

File:

PDF, 220 KB

english, 1991

43

Temporal relationships of cytokine production in mouse non-lethal sepsis: Effect of nitric oxide synthase inhibitors

D. J. Fretland, C. Anglin, D. Widomski, J. Connor, P. Wyatt, P. Manning, M. Currie

Journal:

Inflammation Research

Year:

1997

Language:

english

File:

PDF, 58 KB

english, 1997

44

Specific inhibitors of inducible nitric oxide synthase: Efficacy in a rodent model of sepsis

D. J. Fretland, D. L. Widomski, C. P. Anglin, W. Moore, G. Jerome, C. Kornmeier, J. Connor, L. Branson, P. Wyatt, P. Manning, M. Toth, R. K. Webber, D. Hansen, E. A. Hallinan, T. Hagen, A. Bergmanis,

Journal:

Inflammation Research

Year:

1999

Language:

english

File:

PDF, 113 KB

english, 1999

45

DNA Adduct Levels and Intestinal Lesions in Congenic Rapid and Slow Acetylator Syrian Hamsters Administered the Food Mutagens 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) or 2-Amino-3-methylimidazo[4,5-f]quinoline (IQ

Inger-Lise Steffensen, Adrian J. Fretland, Jan Erik Paulsen, Yi Feng, Tor Jacob Eide, Udaya-Sankar Devanaboyina, David W. Hein, Jan Alexander

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

2000

Language:

english

File:

PDF, 85 KB

english, 2000

46

Non-lethal Sepsis and Nitric Oxide Inhibition in the Guinea Pig

C. H. Fretland, D. L. Widomski, J. M. Thompson

Journal:

Year:

2000

Language:

english

File:

PDF, 67 KB

english, 2000

47

Further Studies with the 2-Amino-1,3-thiazol-4(5H)-one Class of 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors: Reducing Pregnane X Receptor Activity and Exploring Activity in a Monkey Pharmacodynamic Model

Fotsch, Christopher, Bartberger, Michael D., Bercot, Eric A., Chen, Michelle, Cupples, Rod, Emery, Maury, Fretland, Jenne, Guram, Anil, Hale, Clarence, Han, Nianhe

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 441 KB

english, 2008

48

Synthesis and biological activity of new pyridone diaryl ether non-nucleoside inhibitors of HIV-1 reverse transcriptase

Arora, Nidhi, Billedeau, J. Roland, Fretland, Jennifer, Hang, Julie Q., Heilek, Gabrielle M., Harris, Seth F., Hirschfeld, Donald, Javanbakht, Hassan, Li, Yu, Kennedy-Smith, Joshua J.

Journal:

Year:

2010

Language:

english

File:

PDF, 176 KB

english, 2010

49

Cloning, Sequencing, and Recombinant Expression ofNAT1, NAT2,andNAT3Derived from the C3H/HeJ (Rapid) and A/HeJ (Slow) Acetylator Inbred Mouse: Functional Characterization of the Activation and Deactivation of Aromatic Amine Carcinogens

Adrian J. Fretland, Mark A. Doll, Kevin Gray, Yi Feng, David W. Hein

Journal:

Toxicology and Applied Pharmacology

Year:

1997

Language:

english

File:

PDF, 160 KB

english, 1997

50

Higher Frequency of Aberrant Crypt Foci in Rapid Than Slow Acetylator Inbred Rats Administered the Colon Carcinogen 3,2′-Dimethyl-4-aminobiphenyl

Yi Feng, Adrian J. Fretland, Timothy D. Rustan, Wen Jiang, William K. Becker, David W. Hein

Journal:

Toxicology and Applied Pharmacology

Year:

1997

Language:

english

File:

PDF, 389 KB

english, 1997

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